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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352281Generated: October 27, 2026

2-Propyl-6-(3,4,5-trifluorophenyl)-1,2,3,4-tetrahydronaphthalene → 2-Propyl-1,2,3,4-tetrahydro-6-naphthol

https://huagongshe.com/reaction/352281

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Propyl-6-(3,4,5-trifluorophenyl)-1,2,3,4-tetrahydronaphthaleneHCID 22709051—
Reactant2-Propyl-5-fluoro-1,2,3,4-tetrahydro-6-naphtholHCID 22709064—
Solvent2-Propyl-1,2,3,4-tetrahydronaphthalen-6-yl trifluoromethanesulfonateHCID 22709045—
Product2-Propyl-1,2,3,4-tetrahydro-6-naphtholHCID 11240938—
Product2-Propyl-7-fluoro-1,2,3,4-tetrahydro-6-naphtholHCID 22709032—

Reaction Steps

Syntheses were performed in the same manner as (7-2) and (7-3), with the exception of using the 2-propyl-5-fluoro-1,2,3,4-tetrahydro-6-naphthol and the 2-propyl-7-fluoro-1,2,3,4-tetrahydro-6-naphthol obtained in (10-1) above instead of the 2-propyl-1,2,3,4-tetrahydro-6-naphthol in (7-2), and yielded 35 g of 2-propyl-5-fluoro-6-(3,4,5-trifluorophenyl)-1,2,3,4-tetrahydronaphthalene, and 53 g of 2-propyl-7-fluoro-6-(3,4,5-trifluorophenyl)-1,2,3,4-tetrahydronaphthalene respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06746728B1
Source datasetuspto-grants-2004_06
ORD IDord-f4778caf0dc54cbfb39b8dce6cb44ce3
Source noteuspto-grants-2004_06