N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide → N-(2-Chloro-5-methoxy-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide	HCID 9847336	—
Reactant	2-(Bromomethyl)-1-chloro-4-methoxybenzene	HCID 12484533	—
Product	N-(2-Chloro-5-methoxy-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide	HCID 10205188	—

Reaction Steps

The parent compound was obtained as a white solid in comparable yields according to the procedures described above for the preparation of N-methyl-N-(2-methyl-naphthalen-1-ylmethyl)-6-morpholin-4-yl-4-o-tolyl-nicotinamide (Example 19) using 2-chloro-5-methoxy-benzyl bromide instead of 1-chloromethyl-2-methylnaphthalene in step b).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06747026B2
Source dataset	uspto-grants-2004_06
ORD ID	ord-fcb560f914294486a3a50c07b3077aff
Source note	uspto-grants-2004_06