HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Phenylalanine → (2R)-N-[(1S)-1-(1,3-dioxolan-2-yl)-2-phenylethyl]-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Phenylalanine | HCID 6140 | — |
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, (+)- | HCID 6541354 | — |
| Product | (2R)-N-[(1S)-1-(1,3-dioxolan-2-yl)-2-phenylethyl]-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxamide | HCID 69891480 | — |
Reaction Steps
The experimental protocol used is the same as that described for Example 14, with (R)-Trolox being used instead of intermediate 12.1 and the methyl ester of L-phenylalanine replacing the L-Leucine methyl ester. Yellow oil. LC-MS: MH+=426.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06747024B1 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-4bb1a5b7c46747d083d8a1127c92c740 |
| Source note | uspto-grants-2004_06 |