2-Aminopyridine → HCID 22711974, compound

Participants

Reaction Steps

Heat a mixture of 5.7 g of methyl 2-acetyl-5-hexenoate, 3.15 g of 2-aminopyridine and 0.65 g of polyphosphoric acid at 160° C. for 2 hours. Then add, in the cold state, 30 ml of water and extract the mixture using dichloromethane. The residue obtained after evaporating off the solvent is purified by chromatography on silica gel, using a mixture of dichloromethane/methanol: 98/2 as eluant.

Provenance & Evidence