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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352358Generated: October 25, 2026

cis-1-Benzyl-2,6-dimethylpiperazine → cis-1-Acetyl-6-(4-benzyl-3,5-dimethylpiperazin-1-yl)-5-methoxyindoline

https://huagongshe.com/reaction/352358

Reaction equation

Participants

RoleNameHCIDCharge
Reactantcis-1-Benzyl-2,6-dimethylpiperazineHCID 12284911—
Reactant1-Acetyl-6-bromo-5-methoxyindolineHCID 21948375—
Productcis-1-Acetyl-6-(4-benzyl-3,5-dimethylpiperazin-1-yl)-5-methoxyindolineHCID 6983591743%

Reaction Steps

The title compound was prepared in 43% yield from cis-1-benzyl-2,6-dimethylpiperazine (Org. Prep. Proc. 1976, 8, 19) and D1 using a similar procedure to Description 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06747030B1
Source datasetuspto-grants-2004_06
ORD IDord-1c4b6323778248b68d7c9c0145e012b0
Source noteuspto-grants-2004_06