HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylonitrile → 3-{[(1-Benzylpiperidin-4-yl)methyl]amino}propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | (1-Benzyl-4-piperidyl)methanamine | HCID 1514444 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-{[(1-Benzylpiperidin-4-yl)methyl]amino}propanenitrile | HCID 22573229 | 102.4% |
Reaction Steps
A mixture of 1-(phenylmethyl)-4-piperidinemethanamine (0.076 mol) and acrylo-nitrile (0.076 mol) in ethanol (250 ml) was stirred and refluxed for 4 hours. The solvent was evaporated, yielding 20.0 g (102.4%, crude residue, used in next reaction step, without further purification) of 3-[[[1-(phenylmethyl)-4-piperidinyl]methyl]-amino]-propanenitrile (interm. 14).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06747045B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-e426a02ba4e44584bfc1be5fdd089a73 |
| Source note | uspto-grants-2004_06 |