HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-(1,3-dihydroxyprop-2-ylamino)-piperidine → 4-(1,3-Dihydroxyprop-2-ylamino)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-(1,3-dihydroxyprop-2-ylamino)-piperidine | HCID 22712047 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1,3-Dihydroxyprop-2-ylamino)-piperidine | HCID 11206065 | 99.8% |
Reaction Steps
34.5 g of 1-benzyl-4-(1,3-dihydroxyprop-2-ylamino)-piperidine are dissolved in 400 ml of methanol, combined with 3.4 g of 20% palladium/charcoal and hydrogenated with hydrogen at 24-28° C. at 2.2 bar. Then the catalyst is filtered off and the solvent is eliminated in vacuo. 22.7 g of 4-(1,3-dihydroxyprop-2-ylamino)-piperidine are obtained as an oil which is used without further purification for the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06747044B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-3390e956e4e64e2d8602b913a3d6a717 |
| Source note | uspto-grants-2004_06 |