HCID 10120407, compound → HCID 12019497, compound

HRID 352433Notes

Reaction equation

[F:1][C:2]([F:39])([F:38])[C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][N:15]([CH3:37])[C:16](=[O:36])[C@@H:17]([N:24]2[CH2:29][CH2:28][CH:27]([NH:30][CH:31]([CH2:34][OH:35])[CH2:32][OH:33])[CH2:26][CH2:25]2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.FC(F)(F)C1C=C(CCN(C)C(=O)[C@H](OS(C)(=O)=O)C2C=CC=CC=2)C=C(C(F)(F)F)C=1>>[F:38][C:2]([F:1])([F:39])[C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][N:15]([CH3:37])[C:16](=[O:36])[CH:17]([N:24]2[CH2:29][CH2:28][CH:27]([NH:30][CH:31]([CH2:34][OH:35])[CH2:32][OH:33])[CH2:26][CH2:25]2)[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

Reactant 2

HCID 10120407HCID 10120407, compound

HCID 11488562HCID 11488562, compound

Product 1

HCID 12019497HCID 12019497, compound

Procedure

(S)—N-[2-(3,5-Bis-trifluoromethyl-phenyl)-ethyl]-2-[4-(2-hydroxy-1-hydroxymethyl-ethylamino)-piperidin-1-yl]-N-methyl-2-phenylacetamide is obtaine is obtained analogously starting from (R)-N-[2-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-2-methanesulphonyloxy-N-methyl-2-phenyl-acetamide (prepared from D-(−)-mandelic acid).

Workup

customis obtained analogously

Sources & evidence

ORD record: ord-ba05faf1bd254e9ea9994bdeebabe4be
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06747044B2

Reaction notes

Loading…