HCID 22712056, compound → HCID 22712053, compound

Participants

Reaction Steps

13.3 g of 1-benzyl-4-[(2-hydroxy-ethyl)-(3-hydroxy-propyl)-amino]-piperidine are combined with 1.5 g of 10% palladium/charcoal in 150 ml of methanol and hydrogenated at ambient temperature for 18 hours under 5 bars of hydrogen. The catalyst is renewed after 8 and 15 hours. Then the catalyst is filtered off and the filtrate, the solvent, is eliminated in vacuo. 4-[(2-hydroxy-ethyl)-(3-hydroxy-propyl)-amino]-piperidine is obtained as an oil, which is used without further purification for the next reaction.

Provenance & Evidence