3-methyl-N-(1-methylethyl)-2-nitrobenzamide → 2-amino-3-methyl-N-(1-methylethyl)benzamide

HRID 352446노트

반응식

HRID 352446 반응식
[CH3:1][C:2]1[C:3]([N+:14]([O-])=O)=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6].[H][H]>C(O)C.[Pd]>[NH2:14][C:3]1[C:2]([CH3:1])=[CH:13][CH:12]=[CH:11][C:4]=1[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6]

참가 물질

5

반응물 2

HCID 8902723-methyl-N-(1-methylethyl)-2-nitrobenzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 167760932-amino-3-methyl-N-(1-methylethyl)benzamide수율 96.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The 2-nitrobenzamide of Step A (1.70 g, 7.6 mmol) was hydrogenated over 5% Pd/C in 40 mL of ethanol at 50 psi. When the uptake of hydrogen ceased the reaction was filtered through celite and the celite was washed with ether. The filtrate was evaporated under reduced pressure to afford 1.41 g of the title compound as a solid melting at 149-151° C.

후처리

  1. filtrationwas filtered through celite
  2. washthe celite was washed with ether
  3. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e82d6937c51b4cf6911df1f6dd601185
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747047B2

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