反应详情

Thionyl chloride (4.35 g, 36.5 mmol) was added to a mixture of 2-methyl-6-trifluoromethyl nicotinic acid (5.00 g, 24.4 mmol) in 75 mL of toluene and the mixture was heated at reflux for 3 hours. The reaction was cooled to room temperature and the solvent was removed under reduced pressure. Excess thionyl chloride was removed by azeotrope with toluene. The resultant acid chloride was used as is in Example 4, Step B.

1. temperaturethe mixture was heated
2. temperatureat reflux for 3 hours
3. customthe solvent was removed under reduced pressure
4. customExcess thionyl chloride was removed by azeotrope with toluene