HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N,N-dimethyl-3-nitro-aniline → 2-Chloro-3-dimethylaminoaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N,N-dimethyl-3-nitro-aniline | HCID 22712348 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Chloro-3-dimethylaminoaniline | HCID 22712346 | 49.5% |
Reaction Steps
30.4 g of N,N-dimethyl-2-chloro-3-nitroaniline is dissolved in about 300 ml of MeOH and hydrogenated at 20° C. and 5bars pressure of hydrogen using Raney nickel as catalyst. The solvent is evaporated down and the product is purified by chromatography (silica gel, eluant: petroleum ether/ethyl acetate (3/1)). 12.8 g of 2-chloro-3-dimethylaminoaniline is obtained as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06747051B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-9e61eac457a4473dba32450472e134a0 |
| Source note | uspto-grants-2004_06 |