Tramiprosate → HCID 22712117, compound

HRID 352544Notes

Reaction equation

HRID 352544 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][S:5]([OH:8])(=[O:7])=[O:6].[Cl:9][C:10]1[C:11]([F:35])=[N:12][C:13](NCC(OC)=O)=[C:14]([Cl:28])[C:15]=1[O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23]C)=[C:19]([CH:25]([CH3:27])[CH3:26])[CH:18]=1>>[Cl:9][C:10]1[C:11]([F:35])=[N:12][C:13]([NH:1][CH2:2][CH2:3][CH2:4][S:5]([OH:8])(=[O:7])=[O:6])=[C:14]([Cl:28])[C:15]=1[O:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[C:19]([CH:25]([CH3:27])[CH3:26])[CH:18]=1

Participants

3

Reactant 2

HCID 1646TramiprosateHCID 98881843,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridine

Product 1

HCID 22712117HCID 22712117, compound

Procedure

By use of 3-aminopropylsulfonic acid in place of glycine methyl ester ester for the preparation of Compound 1e followed by deprotection as described for example 2.

Sources & evidence

ORD record
ord-ad51efaaf3a3436c99a2054259f8c131
Source dataset
uspto-grants-2004_06
Patent number
US06747048B2

Reaction notes

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