beta-Alanylglycine → 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(3-hydroxycarbonylmethylamino-3-oxopropylamino)pyridine

HRID 352545Notes

Reaction equation

HRID 352545 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5].[Cl:11][C:12]1[C:13]([F:37])=[N:14][C:15](NCC(OC)=O)=[C:16]([Cl:30])[C:17]=1[O:18][C:19]1[CH:24]=[CH:23][C:22]([O:25]C)=[C:21]([CH:27]([CH3:29])[CH3:28])[CH:20]=1>>[Cl:11][C:12]1[C:13]([F:37])=[N:14][C:15]([NH:1][CH2:2][CH2:3][C:4]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5])=[C:16]([Cl:30])[C:17]=1[O:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([CH:27]([CH3:29])[CH3:28])[CH:20]=1

Participants

3

Reactant 2

HCID 137672beta-AlanylglycineHCID 98881843,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridine

Product 1

HCID 207323293,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(3-hydroxycarbonylmethylamino-3-oxopropylamino)pyridine

Procedure

By use of β-alanyl-glycine in place of glycine methyl ester for the preparation of Compound 1e followed by deprotection as described for example 2.

Sources & evidence

ORD record
ord-15f2f0ef47a546ceaf7bc4cef1aa0ded
Source dataset
uspto-grants-2004_06
Patent number
US06747048B2

Reaction notes

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