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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352546Generated: October 25, 2026

Taurine → 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxysulfonylethylamino)pyridine

https://huagongshe.com/reaction/352546

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTaurineHCID 1123—
Reactant3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridineHCID 9888184—
Product3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxysulfonylethylamino)pyridineHCID 22712113—

Reaction Steps

By use of 2-aminoethylsulfonic acid in place of glycine methyl ester for the preparation of Compound 1e followed by deprotection as described for example 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06747048B2
Source datasetuspto-grants-2004_06
ORD IDord-0c10dec69a284944882e38c2d9a60f2f
Source noteuspto-grants-2004_06