Potassium Carbonate → HCID 22712065, compound

Participants

Reaction Steps

To a solution of 3,5-dichloro-2,6-difluoro-4-(3-bromo-4-methoxyphenoxy)pyridine (250 mg) and glycine methyl ester hydrochloric acid (150 mg) in DMF (2.0 mL) was added potassium carbonate powder (250 mg) in one portion. The resulting mixture was stirred at ambient temperature for 20 hours. The reaction mixture was diluted with brine and extracted with ethyl acetate (50 mL×2). The combined organic layers were washed with brine (50 mL×3), dried (Na2SO4) and concentrated. Chromatography with ethyl acetate-hexanes (0-50% gradient elution) provided the title compound as a white solid (253 mg).

Provenance & Evidence