Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3,5-Tribromobenzene → 2-Bromo-1-(2,4,6-tribromo-phenyl)-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3,5-Tribromobenzene | HCID 12279 | — |
| 반응물 | Bromoacetyl bromide | HCID 61147 | — |
| 반응물 | Chloromethyl Thienyl Ketone deriv. 5 | HCID 6539169 | — |
| 생성물 | 2-Bromo-1-(2,4,6-tribromo-phenyl)-ethanone | HCID 10127285 | 45% |
반응 단계
General procedure described for compounds 1 and 2 starting from 1,3,5-tribromobenzene and bromoacetyl bromide. Purified by column chromatography column (hexane:ethyl acetate 6:1), yield 45% m.p.: 86-87° C., 1H-NMR (CDCl3): δ7.7 (s, 2H, Ar), 4.44 (s, 2H, CH2); 13C-NMR (CDCl3): δ193.4 (CO), 139.4 (C—CO), 134.5 (CH), 124.7 (C—Br), 119.4 (C—Br), 34.6 (CH2); M/z (EI): 440, 438, 436, 434, 432 (M+, 1, 3, 5, 3, 1%), 345, 343, 341, 339 (M-CH2Br, 35, 96, 100, 41%); HPLC: Column μ Bondapack C18, 5 μm, 300 A, (300×3.9 mm), Purity 98%, r.t.=3.40 min, acetonitrile/H2O (0.05% H3PO4+0.04% Et3N) 50/50.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06747057B2 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-c5e379a66aa647afbbd28357312b1007 |
| 출처 메모 | uspto-grants-2004_06 |