2-Morpholinoethanol → HCID 10151816, compound

HRID 352569Notes

Reaction equation

[C:1]([CH2:3][NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[C:20]([O:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32]O[CH2:30][CH2:29]1)[CH:19]=2)=[O:15])=[O:6])#[N:2].[N:34]1(CCO)CCOC[CH2:35]1>>[C:1]([CH2:3][NH:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH:13][C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[C:20]([O:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][N:34]([CH3:35])[CH2:30][CH2:29]1)[CH:19]=2)=[O:15])=[O:6])#[N:2]

Participants

Reactant 2

HCID 611632-Morpholinoethanol

HCID 60091049HCID 60091049, compound

Product 1

HCID 10151816HCID 10151816, compound

Procedure

N-((1S,2R)-2-{[(cyanomethyl)amino]carbonyl}cyclohexyl)-6-(2-morpholin-4-ylethoxy)-1H-indole-2-carboxamide using Mitsunobu coupling with 2-morpholin-4-yl-ethanol.

Sources & evidence

ORD record: ord-9e9698bce47948bfa9f17a17618566e7
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06747053B2

Reaction notes

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