Trifluoroacetic acid → HCID 69910139, compound

Participants

Reaction Steps

4-[6-(3-Morpholin-4-yl-prop-1-ynyl)-4-oxo-4H-quinazolin-3-ylmethyl]-benzoic acid tert-butyl ester from the previous step was dissolved in 20 mL of trifluoroacetic acid (“TFA”), and stirred at room temperature for 30 minutes. The TFA was then evaporated in vacuum, and dissolved in dichloromethane. Hexane was then added, which precipitated 4-[6-(3-morpholin-4-yl-prop-1-ynyl)-4-oxo-4H-quinazolin-3-ylmethyl]-benzoic acid trifluoroacetic acid salt as a solid (150 mg). Mass Spec: 404 (M+1), 460 (M+1+TFA). 1H-NMR. DMSO: 3.2-4.4 (broad m, 6H), 5.27 (s, 2H), 7.4 (d, J=8.3 Hz, 2H), 7.72 (d, J=8.6 Hz, 1H), 7.88 (s, 1H), 7.88-7.94 (m, 3H), 8.23 (d, J=1.4 Hz, 1H), 8.64 (s, 1H).

Provenance & Evidence