反应详情

0.123 g (0.35 mmol) of (2S)-2-amino-3-(4-(2-methoxycarbonyl-ethyl)-benzoylamino)-propionic acid tert-butyl ester was dissolved in 2 ml of dimethylformamide and treated with 0.196 ml (1.4 mmol) of triethylamine and 0.164 g (0.7 mmol) of 2-(methoxycarbonyl)-benzenesulfonyl chloride. The solution was stirred for 4 hours at room temperature. The solvent was removed in vacuo, the residue was dissolved in dichloromethane and the solution was washed three times with water. The organic phase was dried with sodium sulfate, filtered and the solvent was removed in vacuo. The residue was chromatographed on silica gel eluting with n-heptane/ethyl acetate (1/1). Yield 75 mg. MS (ES+): m/e=549 (M+H+).

1. customThe solvent was removed in vacuo
2. dissolutionthe residue was dissolved in dichloromethane
3. washthe solution was washed three times with water
4. dry with materialThe organic phase was dried with sodium sulfate
5. filtrationfiltered
6. customthe solvent was removed in vacuo
7. customThe residue was chromatographed on silica gel eluting with n-heptane/ethyl acetate (1/1)