Diethyl Ether → HCID 69838250, compound

Participants

Reaction Steps

A solution of 4-(9-fluorenylmethoxycarbonyl)amino-(4S)-5-chloro-5-hydroxy-imino-pentanoic acid t-butyl ester (3.44 g, 7.50 mmol) and methyl methacrylate (2.40 mL, 3.0 eq) in dry ether under N2 at −78° C. was treated with EtN(i-Pr)2 (1.96 mL, 1.5 eq). Similar treatment as described previously followed by flash chromatography with 25-30% ethyl acetate/hexanes gave 3.46 g (89% overall) of the title compound as diastereomeric mixture.

Provenance & Evidence