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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352727Generated: October 31, 2026

4'-((tert-Butoxycarbonyl)amino)-[1,1'-biphenyl]-2-carboxylic acid → 1-(4-[4-(tert-Butoxycarbonylamino)phenyl]benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

https://huagongshe.com/reaction/352727

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4'-((tert-Butoxycarbonyl)amino)-[1,1'-biphenyl]-2-carboxylic acidHCID 17796572—
ReactantHCID 22710058HCID 22710058—
Product1-(4-[4-(tert-Butoxycarbonylamino)phenyl]benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazineHCID 22711048208.9%

Reaction Steps

In the same manner as in Referential Example 12, a reaction was conducted using 4-[4-(tert-butoxycarbonylamino)phenylbenzoic acid (150 mg) and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine trifluoroacetate (203 mg) as starting materials, whereby the title compound (303 mg, 100%) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06747023B1
Source datasetuspto-grants-2004_06
ORD IDord-912d10bb39de4b09ae02478ad9314783
Source noteuspto-grants-2004_06