Methyl 4-(2-bromoacetyl)benzoate → HCID 178497551, 화합물

HRID 352730노트

반응식

HRID 352730 반응식
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)=O.C([NH:18][C:19]([NH2:21])=[NH:20])(=O)C>C(#N)C>[NH2:21][C:19]1[NH:18][CH:2]=[C:3]([C:5]2[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=2)[N:20]=1

참가 물질

4

반응물 2

HCID 13612771Methyl 4-(2-bromoacetyl)benzoateHCID 178475102HCID 178475102, 화합물

생성물 1

HCID 178497551HCID 178497551, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

At room temperature, methyl 4-bromoacetylbenzoate (1.37 g) and acetylguanidine (1.62 g) were suspended in acetonitrile, followed by heating under reflux for 16 hours. The solvent was then distilled off under reduced pressure. Water was added to the residue. The insoluble matter so precipitated was collected by filtration, followed by washing with ethanol, whereby methyl 4-[2-aminoimidazol-4-yl]benzoate was obtained. The resulting product was dissolved in a mixed solvent of dioxane (10 ml) and 1N hydrochloric acid (10 ml), followed by heating under reflux for 8 hours. The residue obtained by distilling off the solvent was solidified by tetrahydrofuran and then collected by filtration, whereby the title compound (500 mg, 39%) was obtained.

후처리

  1. customAt room temperature
  2. temperatureby heating
  3. temperatureunder reflux for 16 hours
  4. distillationThe solvent was then distilled off under reduced pressure
  5. additionWater was added to the residue
  6. customThe insoluble matter so precipitated
  7. filtrationwas collected by filtration
  8. washby washing with ethanol

출처 및 근거

ORD 기록
ord-e2c6363efed3498790ab769c7aeca721
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747023B1

반응 노트

불러오는 중…