5-Bromopyrimidine-2-carboxylic acid → 1-[(5-Bromopyrimidin-2-yl)carbonyl]-4-[(5-chloroindol-2-yl)sulfonyl]piperazine

HRID 352775Notes

Reaction equation

HRID 352775 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.Cl.[Cl:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]([S:22]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)(=[O:24])=[O:23])=[CH:16]2>>[Br:1][C:2]1[CH:7]=[N:6][C:5]([C:8]([N:28]2[CH2:29][CH2:30][N:25]([S:22]([C:17]3[NH:18][C:19]4[C:15]([CH:16]=3)=[CH:14][C:13]([Cl:12])=[CH:21][CH:20]=4)(=[O:23])=[O:24])[CH2:26][CH2:27]2)=[O:10])=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 164629705-Bromopyrimidine-2-carboxylic acidHCID 227105701-[(5-Chloroindol-2-yl)sulfonyl]piperazine hydrochloride

Product 1

HCID 227095721-[(5-Bromopyrimidin-2-yl)carbonyl]-4-[(5-chloroindol-2-yl)sulfonyl]piperazine

Procedure

In the same manner as in Referential Example 12, a reaction was effected using 5-bromo-2-pyrimidinecarboxylic acid and 1-[(5-chloroindol-2-yl)sulfonyl]piperazine hydrochloride as starting materials, whereby the title compound was obtained as a colorless solid.

Sources & evidence

ORD record
ord-4b4e81ce2d3143f1abba3731cfca128a
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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