1,3-Diethyl 2-oxopropanedioate → HCID 178470501、化合物

HRID 352788ノート

反応式

HRID 352788 の反応式
[CH:1]1[C:6]([C:7]([NH2:10])=[N:8][NH2:9])=[CH:5][CH:4]=[N:3][CH:2]=1.O=[C:12]([C:18](OCC)=[O:19])[C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[O:19]=[C:18]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:9][NH:8][C:7]([C:6]2[CH:5]=[CH:4][N:3]=[CH:2][CH:1]=2)=[N:10]1

参加物

4

反応物 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 5160013N'-aminopyridine-4-carboximidamide

生成物 1

HCID 178470501HCID 178470501、化合物収率 56%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (20 ml), 4-pyridinecarboxyamidrazone (1.48 g) was dissolved. To the resulting solution, diethyl ketomalonate (1.65 ml) was added dropwise at room temperature, followed by stirring for 13 hours. After heating under reflux for 4 hours, the reaction mixture was cooled. Yellow crystals thus precipitated were collected by filtration and dried, whereby the title compound (1.50 g, 56%) was obtained.

後処理

  1. temperatureAfter heating
  2. temperatureunder reflux for 4 hours
  3. temperaturethe reaction mixture was cooled
  4. customYellow crystals thus precipitated
  5. filtrationwere collected by filtration
  6. customdried

出典と根拠

ORDレコード
ord-77a48640e10949998d963b81cf4d6bde
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

反応ノート

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