反应详情

Concentrated hydrochloric acid (3 ml) and palladium hydroxide (683 mg) were added to an ethanol solution (300 ml) of 1,4-dibenzyl-2-(2-methyl-1-propenyl)piperazine (5.2 g), followed by stirring for 2 hours under a hydrogen gas stream of 1 atmospheric pressure. The catalyst was removed by filtration and the solvent was distilled off under reduced pressure. The residue was recrystallized from methylene chloride—hexane, followed by washing with diethyl ether and drying under reduced pressure, whereby the title compound (2.95 g) was obtained as a brown solid.

1. customThe catalyst was removed by filtration
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was recrystallized from methylene chloride—hexane
4. washby washing with diethyl ether
5. dry with materialdrying under reduced pressure, whereby the title compound (2.95 g)
6. customwas obtained as a brown solid