tert-butyl 2-formyl-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate → HCID 69700573, compound

HRID 352852Notes

Reaction equation

HRID 352852 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([CH:17]=O)=[CH:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:19][C@H:20]1[CH2:24][CH2:23][N:22]([S:25]([C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[CH:31][CH:32]=[C:33]([Cl:38])[CH:34]=3)[CH:29]=2)(=[O:27])=[O:26])[CH2:21]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([CH2:17][NH:19][C@H:20]3[CH2:24][CH2:23][N:22]([S:25]([C:28]4[CH:37]=[CH:36][C:35]5[C:30](=[CH:31][CH:32]=[C:33]([Cl:38])[CH:34]=5)[CH:29]=4)(=[O:26])=[O:27])[CH2:21]3)=[CH:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 11845085tert-butyl 2-formyl-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylateHCID 69700279HCID 69700279, compound

Product 1

HCID 69700573HCID 69700573, compound

Procedure

In the same manner as in Referential Example 321, a reaction was effected using 5-tert-butoxycarbonyl-2-formyl -4,5,6,7-tetrahydrothieno[3,2-c]pyridine (WO94/21599) and (3S)-3-amino-1-[(6-chloronaphthalen-2-yl)sulfonyl]pyrrolidine as starting materials, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-7dfcfe7cc6d94b55ae3609ec39600e1a
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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