5-Cyano-1-benzothiophene-2-carboxylic acid → 1-[(6-Chloronaphthalen-2-yl)sulfonyl]-4-[(5-cyanobenzothiophen-2-yl)carbonyl]piperazine

HRID 352854Notes

Reaction equation

HRID 352854 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([C:11]([OH:13])=O)=[CH:8][C:7]=2[CH:14]=1)#[N:2].Cl.[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[C:22]([S:27]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)(=[O:29])=[O:28])[CH:21]=[CH:20]2>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[C:22]([S:27]([N:30]1[CH2:31][CH2:32][N:33]([C:11]([C:9]3[S:10][C:6]4[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:14][C:7]=4[CH:8]=3)=[O:13])[CH2:34][CH2:35]1)(=[O:28])=[O:29])[CH:21]=[CH:20]2

Participants

3

Reactant 2

HCID 108458175-Cyano-1-benzothiophene-2-carboxylic acidHCID 227097661-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride

Product 1

HCID 227108951-[(6-Chloronaphthalen-2-yl)sulfonyl]-4-[(5-cyanobenzothiophen-2-yl)carbonyl]piperazine

Procedure

In the same manner as in Referential Example 319, a reaction was effected using 5-cyanobenzothiophene-2-carboxylic acid and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride as starting materials, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-a0eff3e9eb5c4dce8abdd24991525651
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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