Methanol → HCID 22709528, compound

Participants

Reaction Steps

To a solution of 6-(tert-butoxycarbonyl)-2-formyl-4,5,6,7-tetrahydrooxazol[5,4-c]pyridine (225 mg) in methanol (9.0 ml) were added sodium cyanide (220 mg) and manganese dioxide (780 mg) at room temperature, followed by stirring for 30 minutes. The reaction mixture was subjected to Celite filtration by using ethyl acetate. The filtrate was washed with water (50 ml) and saturated saline (50 ml), dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column (hexane:ethyl acetate=3:2→1:1), whereby the title compound (120 mg) was obtained as a colorless transparent glassy substance.

Provenance & Evidence