1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride → 1-[(6-Chloronaphthalen-2-yl)sulfonyl]-4-[4-(2,4-diaminopyrimidin-6-yl)benzoyl]piperazine Hydrochloride

HRID 352904Notes

Reaction equation

HRID 352904 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[C:5]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=2)[N:4]=1.Cl.[Cl:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[CH:27]=[C:26]([S:31]([N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)(=[O:33])=[O:32])[CH:25]=[CH:24]2>>[ClH:20].[Cl:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[CH:27]=[C:26]([S:31]([N:34]1[CH2:35][CH2:36][N:37]([C:14](=[O:16])[C:13]3[CH:12]=[CH:11][C:10]([C:5]4[N:4]=[C:3]([NH2:2])[N:8]=[C:7]([NH2:9])[CH:6]=4)=[CH:18][CH:17]=3)[CH2:38][CH2:39]1)(=[O:32])=[O:33])[CH:25]=[CH:24]2

Participants

3

Reactant 2

HCID 227097661-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochlorideHCID 694814324-(2,4-Diamino-6-pyrimidyl)benzoic Acid Hydrochloride

Product 1

HCID 227111131-[(6-Chloronaphthalen-2-yl)sulfonyl]-4-[4-(2,4-diaminopyrimidin-6-yl)benzoyl]piperazine Hydrochloride

Procedure

In the same manner as in Example A-4, a reaction was conducted using 4-(2,4-diamino-6-pyrimidyl)benzoic acid hydrochloride and 1-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine hydrochloride as starting materials, whereby the title compound was obtained.

Sources & evidence

ORD record
ord-db80c90a1a474b4b9bd984dcbbc91453
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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