反应详情

5-Benzyloxy-2-methoxybenzaldehyde (150.4 g) was suspended in methanol (600 ml) and to the gently warmed stirred mixture was added, in portions, sodium borohydride (15.0 g). The methanol was evaporated and the residue partitioned between dichloromethane and water. The organic layer was washed with water, then saturated sodium chloride, dried with anhydrous magnesium sulphate and evaporated to dryness. The residue crystallised from dichloromethane/petroleum spirit (40°-60° ) to give 5-benzyloxy-2-methoxybenzyl alcohol (143.8 g, 95%), m.p. 50°-51°.

1. temperatureto the gently warmed
2. customThe methanol was evaporated
3. customthe residue partitioned between dichloromethane and water
4. washThe organic layer was washed with water
5. dry with materialsaturated sodium chloride, dried with anhydrous magnesium sulphate
6. customevaporated to dryness
7. customThe residue crystallised from dichloromethane/petroleum spirit (40°-60° )