HCID 11272253, compound → HCID 22710930, compound

HRID 352939Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([S:13]([N:16]1[CH2:21][CH2:20][N:19]([C:22]([C:24]3[S:25][C:26]4[CH2:27][NH:28][CH2:29][CH2:30][C:31]=4[N:32]=3)=[O:23])[CH2:18][CH2:17]1)(=[O:15])=[O:14])[CH:7]=[CH:6]2.Cl.ClC1C=C2C(=CC=1)C=C(S(N1CC[N:51]([C:54](C3SC4C(C=NO)NC(N)CC=4N=3)=[O:55])CC1)(=O)=O)C=C2>>[C:54]([CH:29]1[NH:28][CH2:27][C:26]2[S:25][C:24]([C:22]([N:19]3[CH2:18][CH2:17][N:16]([S:13]([C:8]4[CH:7]=[CH:6][C:5]5[C:10](=[CH:11][CH:12]=[C:3]([Cl:2])[CH:4]=5)[CH:9]=4)(=[O:14])=[O:15])[CH2:21][CH2:20]3)=[O:23])=[N:32][C:31]=2[CH2:30]1)(=[O:55])[NH2:51]

Participants

Reactant 2

HCID 11272253HCID 11272253, compound

HCID 86592088HCID 86592088, compound

Product 1

HCID 22710930HCID 22710930, compound

Procedure

In a similar manner to Referential Example 33 and Example B-24 by using 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine hydrochloride as a starting material, 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[(6-aminohydroxyiminomethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine hydrochloride and also 1-[(6-carbamoyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine were obtained. 1-[(6-Chloronaphthalen-2-yl)sulfonyl]-4-[(6-aminohydroxyiminomethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine hydrochloride:

Sources & evidence

ORD record: ord-a60df2550d17490392245f5b9e05a05f
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06747023B1

Reaction notes

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