5-chloro-2-(piperazine-1-sulfonyl)-1H-indole → 1-[(5-Chloroindol-2-yl)sulfonyl]-4-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine Hydrochloride

HRID 352944Notes

Reaction equation

HRID 352944 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([S:11]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12])=[CH:5]2.[CH3:20][CH:21]1[NH:26][CH2:25][C:24]2[S:27][C:28]([C:30]([O-])=[O:31])=[N:29][C:23]=2[CH2:22]1.[Li+]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([S:11]([N:14]1[CH2:19][CH2:18][N:17]([C:30]([C:28]3[S:27][C:24]4[CH2:25][NH:26][CH:21]([CH3:20])[CH2:22][C:23]=4[N:29]=3)=[O:31])[CH2:16][CH2:15]1)(=[O:13])=[O:12])=[CH:5]2

Participants

3

Reactant 2

HCID 227105715-chloro-2-(piperazine-1-sulfonyl)-1H-indoleHCID 23674323Lithium 6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate

Product 1

HCID 227111741-[(5-Chloroindol-2-yl)sulfonyl]-4-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine Hydrochloride

Procedure

A reaction was effected in the same manner as in Example B-7 by using 1-[(5-chloroindol-2-yl)sulfonyl]piperazine and lithium 6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-carboxylate as starting materials, whereby the title compound was obtained as brown amorphous.

Sources & evidence

ORD record
ord-3f7967a965dc4129a4f72c4b3120e22a
Source dataset
uspto-grants-2004_06
Patent number
US06747023B1

Reaction notes

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