HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 352998Generated: October 30, 2026
Thionyl Chloride → 3-Trimethylsilylpropanoyl chloride
https://huagongshe.com/reaction/352998
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Trimethylsilyl)propionic acid | HCID 79764 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 3-Trimethylsilylpropanoyl chloride | HCID 564489 | — |
Reaction Steps
13.5 g (0.11 mol) of thionyl chloride are added dropwise with stirring to a mixture of 10 g (0.068 mol) of 3-trimethylsilylpropanoic acid in 30 ml of 1,2-dichloroethane. The reaction mixture is heated at 40° C. for 2 hours. The excess thionyl chloride is removed by distillation under reduced pressure. The solution obtained is used without further purification for the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06749839B2 |
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| Source dataset | uspto-grants-2004_06 |
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| ORD ID | ord-f75ad0c074d34bbf80a4603068007efb |
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| Source note | uspto-grants-2004_06 |
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