Formic Acid → HCID 19601401, compound

HRID 353011Notes

Reaction equation

HRID 353011 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[CH:9](O)=[O:10]>>[CH:9]([O:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:10]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 762881-Pyrrolidineethanol

Product 1

HCID 19601401HCID 19601401, compound

Conditions

Temperature
80 °C

Procedure

A mixture of 115 9 of 1-(2-hydroxyethyl)pyrrolidine and 500 g of formic acid was heated at 80° C. for 10 hours. The reaction mixture was concentrated in vacuum, diluted with ethyl acetate, and neutralized with saturated sodium bicarbonate in water. This was followed by separation, water washing, drying over anhydrous sodium sulfate, and vacuum concentration. Purification by vacuum distillation yielded 2-(1-pyrrolidinyl)ethyl formate, designated (B-10].

Workup

  1. concentrationThe reaction mixture was concentrated in vacuum
  2. additiondiluted with ethyl acetate
  3. customThis was followed by separation, water washing
  4. dry with materialdrying over anhydrous sodium sulfate, and vacuum concentration
  5. customPurification
  6. distillationby vacuum distillation

Sources & evidence

ORD record
ord-fce5b6ab5e7c4e5281802785328ac31a
Source dataset
uspto-grants-2004_06
Patent number
US06749988B2

Reaction notes

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