Sodium Iodide → HCID 22706847, compound

Participants

Reaction Steps

To a suspension of 25 g sodium hydride in 500 g tetrahydrofuran, 131 g of 2-morpholino ethanol and 182 g of tetrahydrofurfuryl bromide were successively added dropwise. Thereafter, 1 9 of sodium iodide was added to the solution, which was heated under reflux for 100 hours. After cooling, the reaction solution was washed with an aqueous saturated sodium chloride solution, concentrated in vacuum, and purified by vacuum distillation, whereby 120 g of 4-[2-(tetrahydrofurfurylmethoxy)ethyl]morpholine, designated [B-43], was obtained (boiling point 97° C./24 Pa, yield: 56%).

Provenance & Evidence