反应详情

温度

100 °C

A mixture of 200 parts of α-(4-fluorophenyl)-1,2-benzenedimethanol and 2295 parts of phosphoric acid 60% was stirred for 3 hours at 100° C. Stirring was continued overnight at room temperature. The reaction mixture was poured onto water and the product was extracted twice with 1,1'-oxybisethane. The combined extracts were washed with water, with a 10% sodium carbonate solution and again with water, dried, filtered and evaporated. The residue was distilled, yielding 57 parts of 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran; bp. 108° C. at 0.2 mm. pressure (intermediate 9).

1. stirringStirring
2. waitwas continued overnight at room temperature
3. additionThe reaction mixture was poured onto water
4. extractionthe product was extracted twice with 1,1'-oxybisethane
5. washThe combined extracts were washed with water, with a 10% sodium carbonate solution and again with water
6. customdried
7. filtrationfiltered
8. customevaporated
9. distillationThe residue was distilled