4-Methylquinoline → HCID 11772090, compound

HRID 353020Notes

Reaction equation

HRID 353020 reaction equation
[N:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4]([CH3:5])=[CH:3][CH:2]=1.[Br:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19]>>[Br-:12].[C:18]([CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][N+:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4]([CH3:5])=[CH:3][CH:2]=1)([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 102854-MethylquinolineHCID 202106-Bromohexanoic acid

Product 1

HCID 11772090HCID 11772090, compoundYield 88.9%

Conditions

Temperature
130 °C

Procedure

See FIG. 3B. A mixture of lepidine (5 g) and 6-bromohexanoic acid (10 g) was heated to 130° C. for 6 h. The solid was washed with acetone and filtered to provide an off-white solid (10.5 g).

Workup

  1. washThe solid was washed with acetone
  2. filtrationfiltered

Sources & evidence

ORD record
ord-bf20e051933c40cc98a2968e70441bd2
Source dataset
uspto-grants-2004_06
Patent number
US06750024B2

Reaction notes

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