Lysine Monohydrate → L-Lysine

Temperature

200 °C

L-lysine monohydrate (821 g, 5.0 mol) and sodium hypophosphite (0.1 g) are placed in a pressurizable 2.5 l reaction vessel and blanketed with nitrogen. The reaction vessel is then sealed and the contents heated at 200° C. for 6 h, during which time the internal pressure rose to 11.2 bar. The pressure is then slowly released to remove water from the reaction mixture. The reaction temperature is maintained at 200° C. for 0.5 h to remove residual amounts of solvent and volatile products. The reaction mixture is then stirred at 200° C. for 25 minutes at 20 mbar of pressure, after which the viscous melt is cooled to 115° C., removed from the reaction vessel and subsequently cooled to ambient temperature. The resulting lysine homo-condensate has a Mw of 4300 daltons.

1. customThe reaction vessel is then sealed
2. customto remove water from the reaction mixture
3. temperatureThe reaction temperature is maintained at 200° C. for 0.5 h
4. customto remove residual amounts of solvent and volatile products
5. temperatureafter which the viscous melt is cooled to 115° C.
6. customremoved from the reaction vessel
7. temperaturesubsequently cooled to ambient temperature

ORD record

ord-38869f472a644c3cb507d44bc1b4b94b

Source dataset

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06750189B1