Morpholine → HCID 53779815, compound

HRID 353047Notes

Reaction equation

HRID 353047 reaction equation
[C:1]([N:8]1[CH2:12][CH2:11][CH:10]([C:13]([OH:15])=O)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[C:4]([O:3][C:1]([N:8]1[CH2:12][CH2:11][CH:10]([C:13]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[O:15])[CH2:9]1)=[O:2])([CH3:5])([CH3:6])[CH3:7]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 27605291-((Tert-butoxy)carbonyl)pyrrolidine-3-carboxylic acid

Product 1

HCID 53779815HCID 53779815, compoundYield 62%

Procedure

The subtitle compound was prepared by the method of Example 5(e) with (R/S)-1-Boc-pyrrolidine-3-carboxylic acid (MacLeod et al J. Med. Chem., 33, 2052 (1990)] and morpholine. The subtitle compound (62%) was obtained as an oil. Rf 0.69 (CH2Cl2/MeOH 95/5, v/v). MS m/z 285 (MH+).

Sources & evidence

ORD record
ord-caa8df84423045798ed6a867da0320a3
Source dataset
uspto-grants-2004_06
Patent number
US06750214B2

Reaction notes

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