反应详情

To a gently stirring solution comprised of 1 molar equivalent of fuming nitric acid in excess concentrated sulfuric acid is added 1 molar equivalent of 4-methyl-benzene-N,N-dimethylsulfonamide in increments. The mixture is stirred for one hour and then poured over chilled water. The mixture is extracted with a suitable solvent like diethyl ether or dichloromethane. The organic phase is dried over a suitable drying agent like magnesium sulfate and concentrated in vacuo to afford a crude product which may be purified by normal methods such as chromatography or crystallization from a solvent like chloroform or heptane.

1. additionpoured
2. extractionThe mixture is extracted with a suitable solvent like diethyl ether or dichloromethane
3. dry with materialThe organic phase is dried over a suitable drying agent like magnesium sulfate
4. concentrationconcentrated in vacuo