Hydrogen Bromide → HCID 69874669, compound

Participants

Reaction Steps

The hydrolysis of compound 1 with HBr in AcOH at 110° C. for 1 h gave furo[2,3-b]quinolin-4-one (2) with 36% yield (B. Klier, O. Schimmer, Mutagenesis 1999, 14, 181). The yield was increased up to 91% by refluxing the reaction mixture for 8 h. This improvement is crucial because the supply of starting dictamnine could be reduced.

Provenance & Evidence