Tetrabutylammonium Fluoride → HCID 9945215, compound

Participants

Reaction Steps

5-{[1-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)-3,5-diethyl-1H-pyrazol-4-yl]sulfanyl}isophthalonitrile (180 mg, 0.4 mmol) (Preparation 51) was treated with tetrabutylammonium fluoride (1M solution in tetrahydrofuran, 0.8 ml, 0.8 mmol) and the resulting solution was stirred for 2½ hours. The mixture was concentrated under reduced pressure to give a brown oil. The crude product was purified by flash chromatography on silica gel eluting with ethyl acetate:dichloromethane (1:4, by volume) to provide the title compound (70 mg) as a yellow oil.

Provenance & Evidence