3,5-Dichlorobenzaldehyde → 3-(3,5-Dichlorobenzylidene)-1,1,1-trifluoro-2,4-hexanedione

Participants

Reaction Steps

The title compound was prepared by a similar method to that of Preparation 9 using 1,1,1-trifluorohexane-2,4-dione and 3,5-dichlorobenzaldehyde. The crude product was purified by flash chromatography on silica gel eluting with a solvent gradient of pentane gradually changing to pentane:ethyl acetate (5:1, by volume). The product was further purified by flash chromatography eluting with dichloromethane:pentane (1:10, by volume) to afford a mixture of the title compounds (500 mg) as a yellow oil.

Provenance & Evidence