4H-Furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine → 9,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

HRID 3531Notes

Reaction equation

HRID 3531 reaction equation
[O:1]1[C:5]2[N:6]=[CH:7][C:8]3[N:9]([CH:11]=[CH:12][CH:13]=3)[CH2:10][C:4]=2[CH:3]=[CH:2]1>C(O)C.[Pd]>[O:1]1[C:5]2[NH:6][CH2:7][C:8]3[N:9]([CH:11]=[CH:12][CH:13]=3)[CH2:10][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 1

HCID 118194714H-Furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

Product 1

HCID 218369669,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1 mmol of 4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine and 0.2 g of 10% Pd/C in 10 ml of 10 ml of ethanol is hydrogenated for 18 hours. The reaction mixture is filtered through diatomaceous earth and the filtrate is evaporated in vacuo to give the desired product as a solid.

Workup

  1. filtrationThe reaction mixture is filtered through diatomaceous earth
  2. customthe filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-dd593ac273974c248c661f856d06b2b8
Source dataset
uspto-grants-1998_03
Patent number
US05733905

Reaction notes

Loading…