Thionyl Chloride → a-(3-Bromopropyl)-4-fluoro-alpha-(4-fluorophenyl)benzeneacetyl chloride

Participants

Reaction Steps

To a stirred solution of 29.5 parts of α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetic acid in 300 parts of trichloromethane were added 28.8 parts of thionyl chloride and the whole was stirred and refluxed for 3 hours. The reaction mixture was evaporated, yielding 30 parts of α-(3-bromopropyl)-4-fluoro-α-(4-fluorophenyl)benzeneacetyl chloride as a residue (intermediate 17).

Provenance & Evidence