Sodium Bicarbonate → HCID 178444681, compound

Participants

Reaction Steps

A solution of 1-hexyl-3,4-dimethyl-4-(3-(5-(trimethylsilyl)-1H-1,2,3-triazol-4-yl)phenyl)piperidine (Example 3, assume 0.64 mmol) in 2 N hydrochloric acid/methanol (1:1, 40 mL) was heated at 90° C. overnight. After allowing to cool, the reaction mixture was adjusted to pH 9 using solid sodium hydrogencarbonate. The aqueous mixture was extracted with ethyl acetate (3×20 mL) and the extracts were dried over MgSO4, filtered and concentrated in vacuo to provide the title compound as a white solid (203 mg, 92%).

Provenance & Evidence