Hydrazinecarboxaldehyde → HCID 178421605, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-benzyl-4-(3-(methoxycarbonimidoyl)phenyl)-4-methylpiperidine (Preparation 12, 735 mg, 2.28 mmol) in methanol (10 mL) was added a solution of formic acid hydrazide (274 mg, 4.56 mmol) in methanol (10 mL). The resultant mixture was stirred for 30 min and then concentrated in vacuo. The residual oil was heated at 100° C. for 1 h and then allowed to cool. This was purified on silica gel (50 g) by column chromatography eluting with a gradient of ethyl acetate:hexane:0.88 ammonia (80:20:1 to 90:10:1) to give the title compound as a clear oil (248 mg, 33%).

Provenance & Evidence