1-Bromohexane → HCID 178444682, compound

Participants

Reaction Steps

To a solution of 4-methyl-4-(3-(1H-1,2,4-triazol-3-yl)phenyl)piperidine (Preparation 45, 55 mg, 0.23 mmol) in N,N-dimethylformamide (2 mL) was added sodium hydrogencarbonate (28 mg, 0.34 mmol) and bromohexane (32 μL, 0.23 mmol). The resultant mixture was heated at 50° C. for 2 h and then allowed to cool. The mixture was partitioned between water (5 mL) and dichloromethane (20 mL). The layers were separated, and the aqueous layer was extracted with dichloromethane (20 mL). The combined extracts were dried over Na2SO4, filtered and concentrated in vacuo and the residue was purified by silica (5 g) column chromatography eluting with methanol:dichloromethane:0.88 ammonia (10:90:1) to give the title compound as a clear oil (7 mg, 9%).

Provenance & Evidence