HCID 11177118, compound → HCID 11295243, compound

HRID 353140Notes

Reaction equation

HRID 353140 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:26][CH:27]([CH3:29])[CH3:28])=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.C(OC(N1CCN(C2[C:52]3[C:47](=[CH:48][C:49](F)=[C:50](F)[CH:51]=3)[N:46]=CN=2)CC1)=O)(C)(C)C>>[CH:27]([O:26][C:20]1[CH:19]=[C:18]2[C:23]([C:14]([N:11]3[CH2:10][CH2:9][N:8]([C:6]([NH:46][C:47]4[CH:48]=[CH:49][C:50]([O:24][C:21]5[CH:22]=[CH:23][CH:18]=[CH:19][CH:20]=5)=[CH:51][CH:52]=4)=[O:7])[CH2:13][CH2:12]3)=[N:15][CH:16]=[N:17]2)=[CH:22][C:21]=1[O:24][CH3:25])([CH3:28])[CH3:29]

Participants

3

Reactant 2

HCID 11177118HCID 11177118, compoundHCID 54134689HCID 54134689, compound

Product 1

HCID 11295243HCID 11295243, compoundYield 100%

Procedure

Substantially the same procedure as in Example 329 was repeated, except that 4-(7-isopropoxy-6-methoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester obtained in Reference Example 9 was used in place of 4-(6,7-difluoro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester, to give the desired compound.

Workup

  1. customobtained in Reference Example 9

Sources & evidence

ORD record
ord-f68804a585034040b78b9e80af5ebeee
Source dataset
uspto-grants-2004_06
Patent number
US06750218B2

Reaction notes

Loading…